Sharp MX-3070N Black-Toner SDS for - Page 7

SAFETY DATA SHEET SECTION 11: Toxicological information 11.1 Information on toxicological effects Information on likely routes of exposure : Inhalation Skin contact Ingestion Eye contact Page : 7/9 Date Issued : Oct.26, 2015 SDS No. F-02571 (US_EN) Acute Toxicity Ingestion(oral) Inhalation Eye irritation Skin irritation Skin sensitizer : LD50 > 2000mg/kg (Rats) : LC50 > 5.0mg/L : Not an irritant (Rabbits) : Not an irritant (Rabbits) : No sensitization Mutagenicity : Negative (Ames Test) Carcinogenicity : In 1996 the IARC reevaluated carbon black as a Group 2B carcinogen (possible human carcinogen). This classification is given to chemicals for which there is inadequate human evidence, but sufficient animal evidence on which to base an opinion of carcinogenicity. The classification is based upon the development of lung tumors in rats receiving chronic inhalation exposures to free carbon black at levels that induce particle overload of the lung. Studies performed in animal models other than rats did not show any association between carbon black and lung tumors. Moreover, a two-year cancer bioassay using a typical toner preparation containing carbon black demonstrated no association between toner exposure and tumor development in rats. Chronic Effect : In a study in rats of chronic inhalation exposure to a typical toner, a mild to moderate degree of lung fibrosis was observed in 92% of the rats in the high concentration (16mg/m3) exposure group, and a minimal to mild degree of fibrosis was noted in 22% of the animals in the middle (4mg/m3) exposure group, but no pulmonary change was reported in the lowest (1mg/m3) exposure group, the most relevant level to potential human exposures. 7 / 9