Oki C941dn C941dn Safety/Warranty/Regulatory Guide - Page 23

11. Toxicological information Information on Toxicological Effects: Acute Toxicity Inhalation Ingestion Skin : No test data available : LD50rat > 5,000mg/Kg 1) : No test data available. Corrosivity/Irritation: Skin Eye : No test data available. : No test data available. Sensitization: Skin : No test data available. Repeated Dose Toxicity : No test data available. In a study in rats of chronic inhalation exposure to a typical toner, a mild to moderate degree of lung fibrosis was observed in 92%of the rats in the high concentration (16mg/m3) exposure group. And a minimal to mild degree of fibrosis was noted in 22% of the animals in the middle (4mg/ m3) exposure group. But no pulmonary change was reported in the lowest (1mg/ m3) exposure group, the most relevant level to potential human exposures. (Muhle et al.) The quantity of toner exhausted with the normal use of this product is estimated less than 1mg/ Carcinogenicity m3 per day. : No test data available. IARC has issued a notice that they will publish amonograph that lists titanium dioxide (tiO2) as possibly carcinogenic to humans (Group 2B) by inhalation (based solely on animal data). Human epidemiology studies do not suggest an increased risk of cancer in humans for occupational exposure to titanium dioxide. IARC stated that exposure levels are assumed to be lower in the user industries, with the possible exception of workers who handle large quantities of titanium dioxide. No significant exposure to titanium dioxide is thought to occur during the use of products in Mutagenicity which titanium dioxide is bound to other materials, such as in paints. 2) : Based on the result of Ames test (Salmonella typhimurium TA98,TA100,TA1535,TA1537, E.coli WP2 uvrA), this product has negative mutagenicity. 1) Toxicity for Reproduction : No test data available. Other Information : Not available. Toxicokinetics, Metabolism : and Distribution Not available. 12. Ecologic information Toxicity : No data available. Persistence and Degradability : No data available. Bioaccumulative Potential : No data available. Mobility in Soil : No data available. Results of PBT and  vPvB Assessment Other Adverse Effects : No results that the component(s) of this product meet(s) the PBT or vPvB criteria under Regulation (EC) No 1907/2006. : No data available. 13. Disposal considerations Waste Treatment Methods : Waste material may be dumped or incinerated on condition that meets all country, state and local environmental regulations. Recommendation: Consult with the disposal agency and the relevant authorities; cleansing agent is water. 14. Transport information 23 - English